島津製作所、メディカル・ケア・サービス、ERISA、島根大学の4者で認知機能に関連する生体マーカーの開発を目的とした共同研究契約を締結

株式会社島津製作所(代表取締役社長 上田輝久)(以下「島津製作所」)、メディカル・ケア・サービス株式会社(代表取締役社長 山本教雄)(以下「MCS」)、株式会社ERISA(代表取締役 河原八郎)(以下「ERISA」)、国立大学法人島根大学(学長 服部泰直)(以下「島根大学」)の4者は、「軽度認知障害における介入アプローチと生体マーカーに関する探索的検討」(以下「本研究」)に関する共同研究契約を締結しました。これに先立ち、島津製作所、MCS等5者はERISAの第三者割当増資を引き受け、7月31日に同社へ計1億4500万円を出資しましたのでお知らせいたします。

厚生労働省によると、認知症患者は2025年には約700万人に達し、65歳以上のシニア層の約5人に1人が認知症になると言われています。それにつれて、医療費や介護費といった社会的費用も増加傾向にあり、慶應義塾大学の研究によると、日本の認知症の社会的費用は2014年時点で総額14.5兆円に上ると試算されています。特に島根県は全国に先駆けて高齢化が進展しており、この課題に対応し島根大学医学部においては認知症の予防に関する研究が早くから行われてきました。

本研究においては、国内最大手の介護事業者であるMCSが事業展開する有料老人ホームを拠点として、認知症予備軍と言われる軽度認知障害(MCI)の方を対象に、認知機能の改善を目的とした介入プログラムを6か月間実施します。また、介入の前後で、島根大学が長年にわたって研究対象として来たfMRI、及び島津製作所が製造販売するfNIRSによる生体マーカー計測を行い、介入効果の評価方法を開発します。本研究は、①脳内の活性部位を可視化する2種類の異なる手法を用いて認知機能との相関を検証する点、及び②計測・医用機器製造販売事業者、統計解析会社、介護事業者、国立大学という認知症予防の技術開発に必要な専門家が提携している点において、独自性の高い画期的な取り組みとなります。本研究により開発された認知機能改善プログラムと評価手法については、日本国内の地方自治体との連携を通じた事業化、及びMCSが事業展開する中国を始めとした世界への事業展開を3社で協力して推進します。

本日(12月3日)に行われた会見より

研究概要

・研究目的 : 本研究では認知症リスクの高い高齢者の進行予防における効果的な介入アプローチと、認知機能と相関する有用な生体マーカーの探索的検討を行う
・被検者人数 : 35名予定
・予定研究期間 : 2018年12月から2020年6月30日(約1年半)
・検査項目 : 認知機能検査、MRI検査、fNIRS検査、血液検査、等

島根大学医学部は日本で最初に脳ドック健診を導入し、一般の健診データと共に脳のMRI画像データ、認知機能データを30年間にわたって継続し蓄積してきました。また前学長の小林祥泰名誉教授は日本脳ドック学会の創設に携わり、脳ドック健診の確立と普及に努め、前医学部長の山口修平教授は同学会の理事として活躍しています。2017年11月にはERISAと共同研究契約を締結して脳MRI画像を用いた認知症の早期検出技術の開発を進めています。

この度、島津製作所、MCS、とっとり地方創生ファンド投資事業有限責任組合2号、株式会社山陰合同銀行、株式会社島根銀行の5者がERISAの第三者割当増資に参加し、事業会社に加えて地域ファンド及び金融も含めて、島根県の医療資産を利用した認知症予防技術の共同開発体制を構築しました。

島津製作所、MCS、ERISA、島根大学は、本研究を通じて、今後とも認知症という大きな社会的課題の解決に相互協力して取り組んでまいります。

各社の概要

■メディカル・ケア・サービス株式会社
所在地 : 埼玉県さいたま市
代表者 : 代表取締役社長 山本教雄
設立 : 1999年
資本金 : 1億円
業務内容 : 国内介護事業(認知症グループホーム、有料老人ホームの開発・運営)・海外介護事業(介護施設の開発・運営及び教育コンサルティング)
    
■株式会社ERISA
所在地 : 島根県松江市
代表者 : 代表取締役 河原八郎
設立 : 2017年
資本金 : 8,250万円
業務内容 : データの統計・分析・解析業務

■国立大学法人島根大学
所在地 : 島根県松江市
代表者 : 学長 服部泰直
設立 : 1949年
資本金 : 387億円
学部 : 法文学部、教育学部、人間科学部、医学部、総合理工学部、生物資源科学部

■株式会社島津製作所
ホームページ URL:https://www.shimadzu.co.jp/

語句説明

軽度認知障害(MCI
認知機能の低下は見られるものの認知症にまで進行していない状態をMCI(Mild Cognitive Impairment:軽度認知障害)と呼びます。

生体マーカー(バイオマーカー)
人の身体の状態を客観的に測定し評価するための指標で、観察、診断、治療に用いられます。非常に多様で分類の仕方も様々ですが、生化学検査、血液検査、腫瘍(しゅよう)マーカーといった臨床検査値、CTやMRI、PETなどの画像診断データのほか、広い意味に捉えた場合には日常の診察に使われる体温や脈拍なども含みます。

MRI(核磁気共鳴画像法・Magnetic Resonance Imaging)
磁気を用いて人間の体内を画像として可視化する技術です。磁石によって作られた磁場を利用するため、人体への影響はほぼないと考えられており、侵襲性の非常に低い検査方法の1つです。水素原子核を磁化させることにより水分を含む体内の部位を可視化させることができるため、水分量が多い血管や脳の診断に用いられています。また、血流の変化を可視化させる機能画像(fMRI)により神経活動を推定することもできます。

fNIRS(機能的近赤外分光法・functional Near-Infrared Spectroscopy)
生体への透過性が高い近赤外光を用いて、生体血流量(酸素化ヘモグロビン、脱酸素化ヘモグロビン)の変化を計測する技術です。この技術を利用した近赤外光脳機能イメージング装置は脳の活動状態を可視化する他の技術の中でも、より自然に近い安全な環境下で簡便に脳の活動状態を測定できます。

291 件のコメント

  • My spouse and I absolutely love your blog and find nearly all
    of your post’s to be just what I’m looking for.
    Do you offer guest writers to write content to suit
    your needs? I wouldn’t mind producing a post or elaborating on a few of the subjects you write related
    to here. Again, awesome website!

  • Aw, this was an exceptionally good post. Finding the time and actual effort to make a
    very good article… but what can I say… I hesitate a whole lot and don’t
    seem to get nearly anything done.

  • Hey would you mind letting me know which webhost you’re using?

    I’ve loaded your blog in 3 different web browsers and I must say this blog loads a lot faster then most.
    Can you recommend a good web hosting provider at a reasonable price?
    Thank you, I appreciate it!

  • Howdy, i read your blog occasionally and i own a similar one and
    i was just curious if you get a lot of spam comments? If so how do
    you stop it, any plugin or anything you can suggest? I get so much lately it’s driving
    me crazy so any assistance is very much appreciated.

    Have a look at my webpage – images3.org

  • Hi there! This is my 1st comment here so I just wanted to give a quick
    shout out and tell you I really enjoy reading your posts.
    Can you suggest any other blogs/websites/forums that go over the same topics?
    Thanks a lot!

  • Wow that was strange. I just wrote an very long comment but after I clicked submit my comment didn’t show up.
    Grrrr… well I’m not writing all that over again. Anyway, just wanted to say
    superb blog!

  • It’s a shame you don’t have a donate button! I’d without a
    doubt donate to this brilliant blog! I guess for now i’ll settle for
    bookmarking and adding your RSS feed to my Google account.
    I look forward to new updates and will talk about this website with my Facebook group.
    Talk soon!

  • Hi! I just wanted to ask if you ever have
    any issues with hackers? My last blog (wordpress) was hacked and I ended up losing a few months of hard work due to
    no backup. Do you have any methods to prevent hackers?

  • When I initially commented I clicked the “Notify me when new comments are added”
    checkbox and now each time a comment is added I get three emails with
    the same comment. Is there any way you can remove me from that service?
    Many thanks!

  • Nice post. I was checking continuously this blog and I’m impressed!
    Very helpful information particularly the last part 🙂 I care for such information much.
    I was looking for this particular info for a very long time.
    Thank you and best of luck.

  • First of all I want to say excellent blog!
    I had a quick question that I’d like to ask if you do not mind.
    I was curious to know how you center yourself and clear your thoughts prior to
    writing. I have had a hard time clearing my thoughts in getting my
    ideas out there. I truly do enjoy writing but it just seems like the first
    10 to 15 minutes are wasted simply just trying to figure out
    how to begin. Any recommendations or hints?
    Cheers!

  • Hello I am so happy I found your site, I really found you by error, while I
    was researching on Aol for something else, Nonetheless I am here now
    and would just like to say many thanks for a tremendous post and a all round enjoyable
    blog (I also love the theme/design), I don’t have time to read it all at the
    moment but I have book-marked it and also included your RSS feeds, so when I have time I will be back to read a great deal more, Please do keep up the great b.

  • When someone writes an article he/she retains the thought of a user in his/her mind
    that how a user can know it. Thus that’s why this article is outstdanding.

    Thanks!

  • Hello there, I do think your site may be having internet browser compatibility issues.
    Whenever I take a look at your site in Safari, it looks fine
    however, if opening in IE, it’s got some overlapping issues.
    I merely wanted to give you a quick heads up! Aside from that,
    great blog!

  • You’ve made some decent points there. I checked on the net to find out more about the issue and found most individuals will go along with your views on this
    site.

  • Link exchange is nothing else except it is only placing the other person’s website link on your page
    at proper place and other person will also do same in favor of
    you.

  • Heya i’m for the first time here. I came across this board and I find It really
    useful & it helped me out a lot. I hope to give something back and help others like you helped me.

  • I got this site from my friend who told me on the topic of this
    web page and at the moment this time I am visiting this web site and
    reading very informative articles or reviews at this place.

  • Thank you for every other magnificent post.
    Where else may anyone get that kind of information in such an ideal manner of writing?
    I’ve a presentation subsequent week, and I am on the look for such info.

  • Hi this is kind of of off topic but I was wondering if blogs use WYSIWYG editors or if you have
    to manually code with HTML. I’m starting a blog soon but have no coding experience so
    I wanted to get guidance from someone with experience.
    Any help would be greatly appreciated!

  • Hi there exceptional blog! Does running a blog such as this require a great deal of work?
    I’ve very little knowledge of computer programming however I had been hoping to start my own blog in the near future.
    Anyway, should you have any suggestions or techniques
    for new blog owners please share. I know this is off subject however I simply wanted to ask.
    Thank you!

  • I am really loving the theme/design of your weblog.
    Do you ever run into any browser compatibility problems?
    A number of my blog readers have complained about
    my website not working correctly in Explorer but looks
    great in Safari. Do you have any solutions to help fix this issue?

  • Hello there! This article could not be written much better!
    Reading through this article reminds me of my previous
    roommate! He constantly kept preaching about this. I am going to send this article to him.
    Pretty sure he will have a very good read. Thanks for sharing!

  • I’ve learn some just right stuff here. Certainly worth bookmarking
    for revisiting. I wonder how so much effort you place to create this sort of wonderful informative web site.

  • I’ve been browsing online more than 2 hours today, yet I never found any interesting article like yours.
    It’s pretty worth enough for me. In my view,
    if all site owners and bloggers made good content as
    you did, the web will be a lot more useful than ever before.

  • I’m not sure where you are getting your info, but great topic.
    I needs to spend some time learning much more or understanding
    more. Thanks for fantastic information I was looking for this info for my mission.

  • I’ve read some just right stuff here. Certainly value bookmarking for revisiting.
    I surprise how a lot effort you place to create this sort of great informative website.

  • Hi, I do believe this is an excellent website. I stumbledupon it 😉 I will come back yet again since I
    bookmarked it. Money and freedom is the greatest way to change, may you be rich and continue to help other people.

  • Hey I know this is off topic but I was wondering
    if you knew of any widgets I could add to my blog that automatically tweet my newest twitter updates.

    I’ve been looking for a plug-in like this for quite some time and was hoping maybe you would have
    some experience with something like this. Please let me know if you
    run into anything. I truly enjoy reading your blog and I look forward to your new updates.

  • I don’t even understand how I stopped up here, however I thought this post was once great.
    I don’t recognise who you might be but definitely
    you’re going to a well-known blogger in case you are not already.
    Cheers!

  • You are so interesting! I do not believe I’ve truly read through
    anything like this before. So great to find somebody with
    a few unique thoughts on this topic. Really.. many thanks for starting
    this up. This web site is something that’s needed on the
    web, someone with a bit of originality!

  • Have you ever thought about including a little bit more than just your articles?
    I mean, what you say is fundamental and everything.

    But just imagine if you added some great visuals or video clips to give your posts
    more, “pop”! Your content is excellent but with images and video clips, this site could definitely be one of the
    very best in its field. Wonderful blog!

  • Heya just wanted to give you a brief heads up and let you
    know a few of the images aren’t loading properly. I’m not sure why but I think its a linking issue.
    I’ve tried it in two different internet browsers and both show the
    same results.

  • Have you ever considered writing an ebook or guest authoring
    on other blogs? I have a blog based upon on the same topics you discuss and would love to have you share some stories/information. I know my audience would value
    your work. If you’re even remotely interested, feel free to send me an email.

  • Hi there, just became alert to your blog through Google, and found that it
    is truly informative. I’m going to watch out for brussels.
    I’ll be grateful if you continue this in future. Numerous people will be
    benefited from your writing. Cheers!

  • Thank you for another informative blog. The place else could I am getting that type of info written in such an ideal means?
    I have a project that I’m simply now running on, and I have been at the glance out for such info.

  • Howdy! Would you mind if I share your blog with my twitter group?
    There’s a lot of people that I think would really enjoy your content.
    Please let me know. Thanks

  • Hey there! Someone in my Myspace group shared this site with us so I
    came to look it over. I’m definitely loving the information. I’m book-marking
    and will be tweeting this to my followers! Great blog and wonderful style and design.

  • You’ve made some good points there. I checked on the net for more info about the issue and found most people will go along with your views on this site.

  • Pretty section of content. I just stumbled upon your weblog and in accession capital to say that I get actually enjoyed account your blog posts.
    Anyway I’ll be subscribing in your augment and even I achievement you get admission to
    persistently fast.

  • Neat blog! Is your theme custom made or did you download it from somewhere?
    A theme like yours with a few simple tweeks
    would really make my blog shine. Please let me know where you got
    your theme. Appreciate it

  • I was extremely pleased to discover this page. I need to to thank you for your time
    just for this wonderful read!! I definitely loved every
    part of it and I have you saved to fav to check out new information in your website.

  • I’m really impressed with your writing skills as well as with the
    layout on your blog. Is this a paid theme or did you modify it yourself?
    Either way keep up the nice quality writing, it is rare to
    see a nice blog like this one today.

  • Can I just say what a relief to find somebody that genuinely
    knows what they’re discussing over the internet. You actually understand
    how to bring a problem to light and make it important.
    More people have to look at this and understand this side of the story.
    I was surprised you’re not more popular since you surely possess the gift.

  • I’ll right away clutch your rss as I can not to find
    your e-mail subscription hyperlink or e-newsletter service.
    Do you’ve any? Kindly allow me realize in order that I could subscribe.
    Thanks.

  • Hello! I’m at work browsing your blog from my new apple iphone!
    Just wanted to say I love reading your blog and look forward to
    all your posts! Carry on the excellent work!

  • Hi, i feel that i saw you visited my weblog thus i
    got here to go back the favor?.I’m trying to in finding issues to improve my site!I suppose
    its ok to use some of your ideas!!

  • When I originally commented I clicked the “Notify me when new comments are added” checkbox and now
    each time a comment is added I get four e-mails with the
    same comment. Is there any way you can remove me from that service?
    Bless you!

  • Excellent blog here! Also your web site loads up fast!
    What web host are you using? Can I get your affiliate link to
    your host? I wish my site loaded up as fast as yours lol

  • I really like your blog.. very nice colors & theme.
    Did you design this website yourself or did you hire someone to do it for you?
    Plz reply as I’m looking to construct my own blog and would like to
    know where u got this from. thank you

  • Having read this I thought it was really enlightening.
    I appreciate you taking the time and effort to put this information together.

    I once again find myself spending a lot of time both reading and leaving comments.
    But so what, it was still worthwhile!

  • I don’t know if it’s just me or if everybody else experiencing problems with your blog.

    It appears as though some of the written text within your content are running off the screen. Can someone else
    please provide feedback and let me know if this is happening to
    them as well? This may be a issue with my internet browser because
    I’ve had this happen before. Kudos

  • Great goods from you, man. I have understand your stuff previous to and you are just too magnificent.
    I really like what you have acquired here, certainly like what
    you’re saying and the way in which you say it. You make it
    entertaining and you still take care of to keep it wise.
    I can not wait to read much more from you. This is actually a terrific
    website.

  • Excellent post. I was checking continuously this blog
    and I’m impressed! Extremely useful info specifically the last part :
    ) I care for such information much. I was seeking this particular information for a long time.
    Thank you and good luck.

  • Hi! I could have sworn I’ve been to this site before but after looking at a few of the articles I realized it’s new to me.

    Anyhow, I’m certainly delighted I discovered it and I’ll be book-marking it and checking back regularly!

  • Hi! Would you mind if I share your blog with my zynga group?
    There’s a lot of folks that I think would really enjoy
    your content. Please let me know. Thank you

  • Hello there I am so delighted I found your blog, I really found you by error,
    while I was looking on Google for something else, Anyways I am here now and would just like to say many thanks for a incredible post
    and a all round entertaining blog (I also love the theme/design), I
    don’t have time to go through it all at the moment
    but I have saved it and also added your RSS feeds, so when I have time
    I will be back to read much more, Please do keep up the superb work.

  • It’s nearly impossible to find knowledgeable people in this particular topic,
    however, you seem like you know what you’re talking about!
    Thanks

  • Just wish to say your article is as surprising. The clarity in your post is just spectacular and
    i could assume you are an expert on this subject.
    Well with your permission let me to grab your feed to keep up to
    date with forthcoming post. Thanks a million and please continue the rewarding work.

  • You really make it seem so easy with your presentation but I find this matter to be
    really something which I think I would never understand.

    It seems too complex and very broad for me.

    I am looking forward for your next post, I will try to get
    the hang of it!

  • Right here is the right web site for anyone who would like to understand this topic.
    You know a whole lot its almost tough to argue with you (not that I
    really will need to…HaHa). You definitely put a fresh spin on a
    topic that’s been discussed for many years. Excellent stuff,
    just wonderful!

  • Oh my goodness! Incredible article dude! Many thanks, However I am encountering troubles with your RSS.
    I don’t know the reason why I am unable to join it. Is there anybody having identical
    RSS problems? Anybody who knows the solution will
    you kindly respond? Thanx!!

  • What’s up to every body, it’s my first pay a quick visit of this webpage;
    this web site consists of amazing and genuinely fine stuff in favor of
    readers.

  • Thanks for ones marvelous posting! I seriously enjoyed reading it, you’re a
    great author.I will always bookmark your blog and will eventually come
    back later in life. I want to encourage that you continue your great work,
    have a nice holiday weekend!

  • Unquestionably consider that that you stated. Your favorite reason seemed to be at
    the net the easiest thing to be mindful of. I say to you, I certainly get irked at the same
    time as other people consider worries that they plainly don’t know about.
    You controlled to hit the nail upon the highest as smartly as outlined out the whole thing with
    no need side-effects , other people could take a signal. Will
    likely be back to get more. Thanks

  • I’ve read several good stuff here. Certainly price bookmarking for revisiting.
    I wonder how so much effort you set to make this type of magnificent informative
    web site.

  • Magnificent beat ! I wish to apprentice while you amend your web site, how could
    i subscribe for a weblog web site? The account helped me a acceptable deal.

    I were a little bit familiar of this your broadcast offered shiny transparent
    concept

  • Hi everyone, it’s my first pay a quick visit at this website, and
    post is truly fruitful designed for me, keep up posting these types of articles.

  • This is really interesting, You’re an excessively skilled blogger.
    I’ve joined your feed and sit up for seeking extra of your fantastic post.
    Also, I’ve shared your website in my social networks

  • Great items from you, man. I have understand your stuff prior to and
    you are just too wonderful. I really like what you’ve obtained right here,
    certainly like what you’re stating and the way wherein you are saying it.

    You make it entertaining and you still take care of to stay it smart.
    I can’t wait to read much more from you. This is really a terrific web site.

  • My brother suggested I might like this blog. He was totally right.
    This post actually made my day. You can not imagine simply how much time I had spent for this info!
    Thanks!

  • Hi, i feel that i saw you visited my blog thus i came
    to return the favor?.I am attempting to find issues to enhance my site!I suppose its
    good enough to use some of your concepts!!

  • Great blog here! Also your website loads up very fast!
    What host are you using? Can I get your affiliate link to your host?
    I wish my site loaded up as quickly as yours lol

  • My spouse and I stumbled over here coming from a different
    page and thought I may as well check things out. I like
    what I see so i am just following you. Look forward to finding
    out about your web page for a second time.

  • I was wondering if you ever considered changing the structure of your site?
    Its very well written; I love what youve got to say.
    But maybe you could a little more in the way of content so people could connect with it better.
    Youve got an awful lot of text for only having one or two images.
    Maybe you could space it out better?

  • Do you mind if I quote a couple of your posts as long
    as I provide credit and sources back to your blog? My blog is in the very same niche as yours
    and my visitors would certainly benefit from a lot of the information you present
    here. Please let me know if this alright with you. Thanks!

  • I know this if off topic but I’m looking into starting my own weblog and was curious what all is required to get setup?

    I’m assuming having a blog like yours would cost a pretty
    penny? I’m not very internet savvy so I’m not 100% sure.
    Any tips or advice would be greatly appreciated. Thank you

  • My programmer is trying to persuade me to move to .net from PHP.

    I have always disliked the idea because of the costs.
    But he’s tryiong none the less. I’ve been using Movable-type
    on a variety of websites for about a year
    and am concerned about switching to another platform.
    I have heard great things about blogengine.net. Is there a way I can transfer all my wordpress content into it?

    Any help would be greatly appreciated!

  • Hello there, I found your website via Google whilst searching for a comparable topic, your site got here up, it
    seems good. I’ve bookmarked it in my google bookmarks.

    Hello there, just turned into alert to your weblog thru Google, and found that
    it’s truly informative. I am going to watch out for
    brussels. I will appreciate in the event you continue this in future.
    Numerous other people shall be benefited out of your writing.
    Cheers!

  • This is very interesting, You’re a very skilled blogger.

    I’ve joined your rss feed and look forward to seeking more of
    your magnificent post. Also, I’ve shared your site
    in my social networks!

  • Hello there I am so happy I found your website, I really
    found you by error, while I was browsing on Bing for something else, Anyhow
    I am here now and would just like to say many thanks for
    a marvelous post and a all round entertaining blog (I also love the theme/design), I don’t have time to
    go through it all at the minute but I have
    book-marked it and also added your RSS feeds, so when I have
    time I will be back to read a great deal more, Please do keep
    up the awesome work.

  • Wow, amazing weblog structure! How lengthy have you been blogging for?
    you made running a blog glance easy. The whole look of your site is magnificent, as
    well as the content!

  • Hey there! Quick question that’s completely off topic.

    Do you know how to make your site mobile friendly?
    My blog looks weird when viewing from my iphone.
    I’m trying to find a template or plugin that might be able to correct this issue.
    If you have any suggestions, please share. With thanks!

  • Greetings from Colorado! I’m bored to death at work so I decided to check out your
    site on my iphone during lunch break. I love the information you provide here and can’t wait to take a look when I get home.
    I’m shocked at how fast your blog loaded on my phone ..
    I’m not even using WIFI, just 3G .. Anyhow, very good
    blog!

  • Hi there, You’ve done an incredible job. I’ll certainly digg it and personally recommend to
    my friends. I am sure they will be benefited from this website.

  • Terrific work! That is the kind of info that should be shared
    around the web. Disgrace on the seek engines for now not positioning this post higher!
    Come on over and consult with my website .
    Thank you =)

  • A person necessarily assist to make seriously
    posts I might state. That is the very first time I frequented
    your website page and so far? I surprised with the analysis you made
    to create this actual post amazing. Fantastic process!

  • I just like the valuable info you supply in your articles.
    I’ll bookmark your weblog and take a look at once more here frequently.
    I am slightly sure I will learn lots of new stuff right right here!
    Good luck for the next!

  • Hello There. I found your weblog using msn. This is an extremely neatly written article.
    I’ll make sure to bookmark it and return to learn extra of your useful info.

    Thank you for the post. I’ll certainly comeback.

  • An impressive share! I have just forwarded this
    onto a coworker who has been doing a little homework on this.
    And he actually ordered me dinner because I discovered it for him…
    lol. So allow me to reword this…. Thanks for the meal!! But yeah, thanx for spending time to discuss this topic
    here on your web site.

  • A fascinating discussion is definitely worth comment.
    I do believe that you ought to write more about this issue, it might not be a taboo subject
    but typically folks don’t discuss these topics. To the next!
    Best wishes!!

  • I simply couldn’t depart your web site prior to suggesting
    that I extremely loved the usual information a person provide for your
    guests? Is going to be again incessantly in order to check
    up on new posts

  • Can I simply say what a comfort to uncover someone that really understands what they’re talking about on the net.
    You actually know how to bring an issue to light and make it important.
    A lot more people should read this and understand this side of your story.
    I can’t believe you are not more popular because you most certainly have the gift.

  • Woah! I’m really loving the template/theme of this site.

    It’s simple, yet effective. A lot of times it’s very hard to get that
    “perfect balance” between user friendliness and visual appeal.
    I must say that you’ve done a great job with this.
    In addition, the blog loads extremely fast for me on Safari.
    Excellent Blog!

  • I know this website gives quality depending articles or reviews and extra information, is
    there any other site which provides these kinds of things in quality?

  • Heya i’m for the first time here. I came across this board and I find
    It really useful & it helped me out much. I’m hoping to present one
    thing back and help others such as you helped me.

  • Pretty nice post. I simply stumbled upon your weblog
    and wanted to mention that I have really enjoyed surfing around your weblog posts.
    In any case I’ll be subscribing on your rss feed and I’m hoping you write once more soon!

  • Hey would you mind letting me know which hosting company you’re using?
    I’ve loaded your blog in 3 completely different internet
    browsers and I must say this blog loads a lot faster then most.
    Can you recommend a good internet hosting provider at a
    honest price? Cheers, I appreciate it!

  • I’m excited to find this page. I want to to thank you for your time just for
    this wonderful read!! I definitely appreciated every part of it and I have you saved as a favorite to see new stuff in your blog.

  • Have you ever thought about publishing an ebook or guest authoring on other blogs?
    I have a blog based on the same information you discuss
    and would love to have you share some stories/information.
    I know my viewers would value your work. If you are even remotely
    interested, feel free to send me an email.

  • Very nice post. I just stumbled upon your blog and wished to say that I have truly enjoyed browsing your blog
    posts. After all I will be subscribing to your feed
    and I hope you write again very soon!

  • Thanks for the marvelous posting! I truly enjoyed reading it, you can be a great author.I
    will make sure to bookmark your blog and definitely will come back someday.
    I want to encourage you to definitely continue your great work, have
    a nice day!

  • Thank you a bunch for sharing this with all people you actually know what you’re speaking approximately!
    Bookmarked. Kindly additionally talk over with my web site =).
    We could have a hyperlink trade agreement between us

  • Thank you for every other great post. The place else may anyone get that
    type of information in such a perfect way of writing?
    I’ve a presentation next week, and I am on the search for such info.

  • I’m extremely impressed with your writing skills and also with the layout on your blog.
    Is this a paid theme or did you modify it yourself?
    Anyway keep up the excellent quality writing, it’s rare to see
    a great blog like this one nowadays.

  • Hello there, I found your blog by the use of Google whilst looking for a similar matter, your website got here up, it looks great.

    I have bookmarked it in my google bookmarks.

    Hello there, just become aware of your weblog
    via Google, and located that it’s truly informative.
    I am going to watch out for brussels. I will appreciate
    for those who proceed this in future. Many people shall be benefited from your writing.
    Cheers!

  • I’m not sure exactly why but this blog is loading incredibly slow for
    me. Is anyone else having this problem or is it a problem on my end?
    I’ll check back later on and see if the problem still exists.

  • This design is wicked! You most certainly know how to keep a reader amused.
    Between your wit and your videos, I was almost moved to start my own blog (well, almost…HaHa!) Great job.
    I really loved what you had to say, and more than that, how you presented it.

    Too cool!

  • A fascinating discussion is definitely worth comment.
    I do believe that you ought to write more on this subject matter, it may not be a taboo matter but typically people don’t discuss these issues.
    To the next! Many thanks!!

  • Greetings! I know this is somewhat off topic
    but I was wondering which blog platform are you using for this site?
    I’m getting sick and tired of WordPress because I’ve had problems with hackers and I’m looking at alternatives for another
    platform. I would be great if you could point me in the direction of a good platform.

  • excellent put up, very informative. I ponder why the opposite
    experts of this sector do not notice this. You must proceed your writing.
    I am sure, you have a huge readers’ base already!

  • Hello are using WordPress for your site platform? I’m new to the blog world but I’m trying
    to get started and create my own. Do you need any coding knowledge to make your own blog?
    Any help would be greatly appreciated!

  • My brother suggested I would possibly like this website.
    He was totally right. This submit truly made my day.

    You cann’t believe simply how a lot time I had spent for this information! Thanks!

  • I like the valuable information you provide in your articles.

    I’ll bookmark your weblog and check again here regularly.
    I am quite certain I’ll learn lots of new stuff right here!
    Good luck for the next!

  • I’m impressed, I must say. Rarely do I come across a blog that’s both educative and engaging, and let me tell you, you
    have hit the nail on the head. The issue is an issue that not enough people
    are speaking intelligently about. Now i’m very happy I came across this during my hunt for
    something concerning this.

  • Excellent post however I was wanting to know if you could write a litte more on this topic?

    I’d be very grateful if you could elaborate a little bit further.

    Many thanks!

  • I like the helpful information you provide in your articles.
    I’ll bookmark your blog and check again here regularly.
    I am quite sure I’ll learn plenty of new stuff right here!
    Best of luck for the next!

  • Admiring the time and effort you put into your site and
    in depth information you present. It’s awesome to come
    across a blog every once in a while that isn’t the same
    out of date rehashed information. Wonderful read! I’ve saved your site and I’m including your RSS
    feeds to my Google account.

  • I am extremely impressed with your writing skills and also with the layout on your blog.
    Is this a paid theme or did you modify it yourself?
    Anyway keep up the excellent quality writing, it is rare to see a great blog like this one today.

  • Spot on with this write-up, I honestly feel this amazing site needs much
    more attention. I’ll probably be returning
    to read through more, thanks for the information!

  • I’m not sure where you are getting your information, but good topic.

    I needs to spend some time learning much more or understanding more.
    Thanks for magnificent information I was looking for this info
    for my mission.

  • Your style is really unique compared to other folks I’ve read stuff from.
    I appreciate you for posting when you have the opportunity, Guess I will
    just book mark this blog.

  • Hello there! Quick question that’s entirely off topic.
    Do you know how to make your site mobile friendly?

    My blog looks weird when browsing from my apple iphone. I’m trying to find a
    template or plugin that might be able to correct this issue.

    If you have any suggestions, please share. Many thanks!

  • Hi there every one, here every person is sharing these familiarity, thus it’s nice to
    read this blog, and I used to pay a quick visit this weblog everyday.

  • Do you mind if I quote a couple of your articles as long as I provide credit and
    sources back to your weblog? My website is in the very same area
    of interest as yours and my users would genuinely benefit from some of the information you present here.

    Please let me know if this okay with you. Thanks a lot!

  • You really make it seem so easy with your presentation but I find this topic to be really something that I think I would never understand.
    It seems too complex and extremely broad for me.
    I’m looking forward for your next post, I’ll try to get the hang of it!

  • I’m really impressed with your writing talents as well as with the format to your blog.
    Is that this a paid subject matter or did you modify it yourself?
    Either way stay up the excellent quality writing, it is rare to peer a nice weblog like this one
    today..

  • great issues altogether, you simply received a emblem new reader.
    What may you suggest about your publish that you just made some days in the past?

    Any certain?

  • Hi there! I could have sworn I’ve been to this site before but after browsing through some of the post I realized it’s new to me.
    Anyways, I’m definitely delighted I found it and I’ll be book-marking and checking back frequently!

  • I got this web page from my friend who shared with me about this web page and now
    this time I am browsing this site and reading very informative posts at this place.

  • Howdy! I realize this is somewhat off-topic however I had
    to ask. Does operating a well-established website such as
    yours take a large amount of work? I’m brand new to writing
    a blog but I do write in my journal every day. I’d like
    to start a blog so I can share my personal experience and feelings online.
    Please let me know if you have any kind
    of recommendations or tips for new aspiring bloggers.
    Thankyou!

  • Wow, incredible weblog structure! How lengthy have you
    been running a blog for? you make blogging look easy. The total
    look of your web site is wonderful, as neatly as the content!

  • It’s remarkable to pay a quick visit this site and reading the views of all
    colleagues concerning this article, while I am also eager
    of getting familiarity.

  • Please let me know if you’re looking for a article author for your blog.
    You have some really great posts and I think I would be a good asset.

    If you ever want to take some of the load off, I’d love to write some material
    for your blog in exchange for a link back to mine.
    Please send me an e-mail if interested. Many thanks!

  • Does your blog have a contact page? I’m having trouble locating
    it but, I’d like to send you an e-mail. I’ve got some creative ideas for your blog you might be interested in hearing.
    Either way, great site and I look forward to seeing it grow over time.

  • Link exchange is nothing else but it is just placing the
    other person’s web site link on your page at suitable place and
    other person will also do similar in favor of you.

  • Aw, this was an extremely nice post. Spending some time and
    actual effort to generate a good article… but what can I say… I procrastinate
    a whole lot and don’t manage to get anything done.

  • It’s actually very difficult in this busy life to listen news
    on TV, thus I just use web for that purpose, and get the most up-to-date information.

  • Admiring the dedication you put into your website and detailed
    information you offer. It’s good to come across a blog every once in a while that isn’t the same
    old rehashed information. Great read! I’ve saved your site and
    I’m including your RSS feeds to my Google account.

  • I am curious to find out what blog system you’re using? I’m experiencing some small security
    issues with my latest blog and I would like to find something more
    risk-free. Do you have any recommendations?

  • Heya! I know this is sort of off-topic however I had to ask.

    Does running a well-established website like yours require a large amount of work?
    I am completely new to writing a blog but I do
    write in my journal every day. I’d like to start a blog so I can share my personal experience and thoughts
    online. Please let me know if you have any suggestions or tips for new aspiring bloggers.
    Appreciate it!

  • Woah! I’m really loving the template/theme of this website.
    It’s simple, yet effective. A lot of times
    it’s hard to get that “perfect balance” between user friendliness and appearance.
    I must say you’ve done a amazing job with this. In addition, the blog loads extremely fast for me on Safari.
    Outstanding Blog!

  • Greetings from Ohio! I’m bored at work so I decided to browse your website
    on my iphone during lunch break. I really like the info you present here and can’t
    wait to take a look when I get home. I’m surprised at how
    quick your blog loaded on my phone .. I’m not even using WIFI, just 3G
    .. Anyways, wonderful blog!

  • This is very interesting, You’re a very skilled blogger.
    I have joined your rss feed and look forward to seeking more of
    your fantastic post. Also, I have shared your web site in my social networks!

  • Hello I am so delighted I found your site, I really found you by mistake,
    while I was researching on Google for something else, Anyways I am here now and would just like to say many
    thanks for a incredible post and a all round interesting blog (I also love the theme/design), I
    don’t have time to go through it all at the minute but I have
    saved it and also included your RSS feeds, so when I have time I
    will be back to read more, Please do keep up the excellent jo.

  • I like the helpful information you supply in your articles.
    I will bookmark your weblog and test again right here regularly.

    I’m reasonably certain I will be informed lots of new
    stuff right right here! Best of luck for the next!

  • What’s Happening i’m new to this, I stumbled upon this I’ve discovered It absolutely helpful
    and it has aided me out loads. I’m hoping to contribute & assist
    different users like its aided me. Good job.

  • Greetings! I know this is kinda off topic however I’d figured I’d
    ask. Would you be interested in trading links or maybe guest authoring a blog article or vice-versa?
    My website addresses a lot of the same topics as yours and I
    believe we could greatly benefit from each other.
    If you’re interested feel free to send me an email. I look forward to hearing from you!
    Excellent blog by the way!

  • Hello there! This post couldn’t be written much better! Looking at this article reminds me of my previous roommate!
    He constantly kept preaching about this. I will send this information to
    him. Pretty sure he’ll have a great read. Many thanks for sharing!

  • Hi, i think that i saw you visited my website thus i came to “return the favor”.I’m trying to find things to enhance
    my website!I suppose its ok to use some of your ideas!!

  • Simply want to say your article is as amazing. The clarity in your post is just cool
    and i can assume you’re an expert on this subject. Fine with your permission let me to grab your feed to keep updated
    with forthcoming post. Thanks a million and please continue
    the gratifying work.

  • Wow, incredible blog layout! How long have you been blogging for?
    you made blogging look easy. The overall look of your website is magnificent, as well as the content!

  • Howdy I am so glad I found your blog, I really found you by mistake, while I was
    searching on Aol for something else, Nonetheless I am here now and would just like to say thanks a lot for
    a remarkable post and a all round enjoyable blog (I also love the theme/design),
    I don’t have time to look over it all at the moment but I have book-marked it and also added your RSS feeds, so when I have time
    I will be back to read a great deal more, Please do keep up the awesome work.

  • Hello there! This post could not be written much better! Looking through this article reminds me of my previous roommate!
    He continually kept talking about this. I am going
    to forward this information to him. Fairly certain he’ll have a good read.

    Thanks for sharing!

  • Write more, thats all I have to say. Literally, it seems
    as though you relied on the video to make your point.
    You definitely know what youre talking about, why throw away your intelligence on just
    posting videos to your site when you could be giving
    us something enlightening to read?

  • I have been exploring for a little for any high quality articles or blog posts on this kind of space .
    Exploring in Yahoo I ultimately stumbled upon this website.
    Studying this information So i’m satisfied to convey that I have an incredibly good uncanny
    feeling I found out exactly what I needed. I so much unquestionably will make sure to do not disregard this site and give it
    a look on a constant basis.

  • Thanks for any other informative blog. The place else could I get that kind of information written in such an ideal means?

    I’ve a mission that I’m simply now working on, and I have been at the look out
    for such info.

  • Excellent post. I was checking continuously this blog and I am impressed!
    Extremely useful information specially the last part 🙂 I care for
    such info a lot. I was looking for this particular information for a very long time.
    Thank you and good luck.

  • Greetings from Ohio! I’m bored to tears at work so I decided to check out your blog on my iphone during lunch break.
    I love the information you provide here and can’t wait
    to take a look when I get home. I’m surprised at how fast your blog loaded on my mobile ..
    I’m not even using WIFI, just 3G .. Anyhow, very good blog!

  • Today, I went to the beach with my kids. I found a sea shell and gave it to my 4 year old daughter and said “You can hear the ocean if you put this to your ear.” She placed the shell to her ear and screamed.
    There was a hermit crab inside and it pinched
    her ear. She never wants to go back! LoL I know this is entirely off topic but I had
    to tell someone!

  • Appreciating the dedication you put into your site and detailed information you present.
    It’s nice to come across a blog every once in a while that isn’t the same out of date rehashed information. Great read!
    I’ve saved your site and I’m including your RSS feeds to my Google account.

  • Fantastic post however , I was wondering if you could write a litte more on this subject?
    I’d be very grateful if you could elaborate a little bit more.
    Thanks!

  • Thank you for the good writeup. It in fact was a amusement
    account it. Look advanced to far added agreeable from you!
    By the way, how could we communicate?

  • Hi, i think that i saw you visited my site thus i got here to go back the prefer?.I am attempting to in finding issues to improve my
    web site!I suppose its adequate to make use of a few of your ideas!!

  • I’m really enjoying the theme/design of your web site.
    Do you ever run into any browser compatibility problems?
    A couple of my blog readers have complained about my website not working correctly in Explorer but looks
    great in Opera. Do you have any tips to help fix this issue?

  • magnificent publish, very informative. I ponder why the opposite experts of this sector do not understand
    this. You should proceed your writing. I am sure, you have a huge
    readers’ base already!

  • Hi, I think your site might be having browser compatibility issues.
    When I look at your blog in Opera, it looks fine but when opening in Internet Explorer, it has some overlapping.
    I just wanted to give you a quick heads up! Other then that, great
    blog!

  • I’m really enjoying the theme/design of your weblog. Do you
    ever run into any web browser compatibility issues? A number of my blog readers
    have complained about my website not working correctly in Explorer but looks great
    in Firefox. Do you have any ideas to help fix this issue?

  • I’m truly enjoying the design and layout of your site. It’s a very
    easy on the eyes which makes it much more pleasant for me to come here and
    visit more often. Did you hire out a designer to create your theme?

    Exceptional work!

  • When I originally commented I clicked the “Notify me when new comments are added” checkbox and now each time a comment is
    added I get several emails with the same comment.
    Is there any way you can remove people from that service?
    Thank you!

  • Magnificent beat ! I would like to apprentice while you
    amend your web site, how can i subscribe for a blog website?
    The account aided me a acceptable deal. I had
    been a little bit acquainted of this your broadcast provided bright
    clear concept

  • Nice post. I learn something totally new and challenging on blogs I
    stumbleupon on a daily basis. It will always be interesting to read articles from
    other authors and practice a little something from other web
    sites.

  • You really make it appear so easy along with your
    presentation but I in finding this topic to be actually one thing which I believe I would
    never understand. It sort of feels too complicated and extremely
    wide for me. I am looking ahead on your next put up, I’ll try to get the grasp of it!

  • I think this is one of the most significant information for me.

    And i am glad reading your article. But want to remark on some general
    things, The web site style is ideal, the articles is really
    great : D. Good job, cheers

  • Nice blog right here! Also your web site loads up fast!
    What host are you using? Can I get your affiliate hyperlink on your host?
    I wish my website loaded up as fast as yours lol

  • Hey! This post couldn’t be written any better!
    Reading this post reminds me of my good old room mate!
    He always kept talking about this. I will forward this post to him.
    Fairly certain he will have a good read. Thanks for sharing!

  • コメントを残す

    メールアドレスが公開されることはありません。 * が付いている欄は必須項目です